Evaluation of indirect sequence-specific magneto-extraction-aided LAMP for fluorescence and electrochemical SARS-CoV-2 nucleic acid detectionArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, 치료제, [키워드] amplification approach circumvent clinically Disadvantages Electrochemical LAMP Host in silico inhibitor investigated isothermal isothermal amplification Magnetic sequence-specific target enrichment molecular NAAT nucleic acid Nucleic acid detection PCR polymerase probe qRT-PCR Quantitative Quantitative real-time LAMP real-time reverse transcriptase restrict SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 variant SARS-CoV-2. sensitivity sequence serum turn [DOI] 10.1016/j.talanta.2022.123809 PMC 바로가기
Strategies to tackle SARS-CoV-2 Mu, a newly classified variant of interest likely to resist currently available COVID-19 vaccines현재 사용 가능한 COVID-19 백신에 저항할 가능성이 있는 새로 분류된 관심 변종인 SARS-CoV-2 Mu에 대처하기 위한 전략Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adopted approach B.1 lineage B.1.621 BNT161b2 booster dose Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccine development Evidence exacerbated Genetic genomic Genomic surveillance global mass vaccination Health implementation infections Intervention Lineage mass vaccination Mu variant mutations Neutralizing non-pharmaceutical interventions (NPIs) NPIs potential risk public health measure public health measures Recombination reported required respiratory restrict SARS-CoV-2 SARS-CoV-2 B.1.621 SARS-CoV-2 virus sera shown Strains Strategy sub-lineage B.1.621.1 Surveillance survivor the SARS-CoV-2 virus therapeutic threat vaccination Vaccine vaccine breakthrough. Vaccine development variant variants [DOI] 10.1080/21645515.2022.2027197 PMC 바로가기 [Article Type] Article
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA virusesArticle Published on 2022-11-072022-11-16 Journal: EMBO Reports [Category] SARS, 변종, [키워드] Antiviral approach cell line Complexes CRISPR DDX42 DDX42 DEAD-box RNA helicase Depletion DNA dominant-negative elements expression Helicase HIV-1 HIV-1 infection identify immunoprecipitation in vitro increase Infection inhibit inhibitor Interaction intrinsic intrinsic immunity LINE-1 mutant overexpression Perspective primary cells Replication restrict reverse transcription ribonucleoprotein RNA RNA virus RNA viruses RNA-seq analysis SARS-CoV-2 target cells viral infections viral inhibition. viruses [DOI] 10.15252/embr.202154061 PMC 바로가기
Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19Article Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-inflammatory cytokine CD4 CD8 Cell Cell-based therapy conserved Conserved T cell epitope Coronavirinae coronavirus coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 in patients current epitope global public health help highlight Human identification Immunity infect Infection Inflammatory monoclonal antibody mutant new SARS-CoV-2 omicron outbreak pandemic PROTECT Protein RdRP restrict RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants secreted Seven specificity T cell T cells targeted epitope TCR TCR-T therapy. therapy transducing Treatment unique Vaccine variant variants [DOI] 10.1016/j.intimp.2022.109283 PMC 바로가기
SARS-CoV-2 Transmission Prevention Model Application in a Large Retail Company Before the Vaccine IntroductionArticle Published on 2022-10-142022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] activities activity antigenic application body temperature company Contagion control group country COVID-19 detect distribution early stage Food industry Health hospitals Italian legislation Italy lockdown measure Measures Model National pandemic pandemic status pharmacies positive prevention protocol provided public health measure reduce reduction restrict SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 prevention serological test significantly Spread state subject Swab Telemedicine Transmission transmission prevention model vaccination virus was selected WHO Workplace. [DOI] 10.3389/fpubh.2022.908690 PMC 바로가기
The Impact of the COVID-19 Pandemic on Adolescent Mental Health and Substance UseRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: The Journal of adolescent health : official public [Category] 임상, [키워드] Adolescent adolescents age alcohol Anxiety Asian black changes in Community COVID-19 COVID-19 pandemic Depression determine female Health Impact Increased individual level Interaction Isolation Latinx limit loneliness mental health mitigate Odds ratio participant physical poor mental health Randomized controlled trial recruited resource restrict School Stress substance Substance use substance use. symptoms of depression variety Wave white [DOI] 10.1016/j.jadohealth.2022.05.025 PMC 바로가기 [Article Type] Randomized Controlled Trial
Trends in counterfeit drugs and pharmaceuticals before and during COVID-19 pandemicReview article Published on 2022-09-012022-10-05 Journal: Forensic science international [Category] 치료기술, 치료제, [키워드] Adulterated Combination Counterfeit COVID-19 COVID-19 pandemic distress drug drugs Efficacy expressed Falsified Health health systems healthcare providers limitation measure Medicine Medicines outbreak pandemic Panic Perspective Pharmaceuticals proliferation public health public health emergency recommendations reported restrict risk trend Vaccines [DOI] 10.1016/j.forsciint.2022.111382 [Article Type] Review article
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review
Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escapeOmicron SARS-CoV-2 돌연변이는 스파이크 업-RBD 형태를 안정화하고 비-RBM-결합 단일클론 항체 탈출을 유도합니다Article Published on 2022-08-242022-09-11 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Accessibility ACE2 binding analysis antibody complexes conformational change cryo-EM ENhance epitope expand human ACE2 immune evasion mechanism monoclonal antibody Mutation neutralizing antibody omicron performed Prevent prototype Receptor binding restrict S309 SARS-CoV-2 SARS-CoV-2 mutation stability Substitution substitutions target triggered up-RBD variants of concern VOCs [DOI] 10.1038/s41467-022-32665-7 PMC 바로가기 [Article Type] Article
Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: A comparative analysis across two New York hospitals입원한 COVID-19 환자의 사망 위험을 결정하기 위해 환자 바이오마커 시계열을 사용: 두 뉴욕 병원에 대한 비교 분석Article Published on 2022-08-182022-09-11 Journal: PLoS ONE [Category] SARS, 바이오마커, 치료기술, [키워드] Accuracy Admission Analysis Bayesian Biomarker Biomarkers center changes in clinical measurement cohorts COVID-19 COVID-19 patient death determine died difficulty discharge discharged explain Factor focus generalisability Health Sciences high risk high risk patients highlight hospital hospitalisation hospitalised hospitals Maimonide Maimonides Markov median Model Mortality mortality risk New New York outcome Patient patient cohort patient cohorts patient mortality patients Predictive prognostic model Prognostic models question raising restrict risk risk of COVID-19 Science sensitivity single hospital state tested university utility variables [DOI] 10.1371/journal.pone.0272442 PMC 바로가기 [Article Type] Article